10/30/2023 0 Comments Download vitamin d k2The subjects TFs and microRNA species appeared to be part of an intricate hierarchical structure encompassing several classes of HDACs, including the Sirtuins, known to respond to cellular energy status (i.e. With the aid of various algorithms, one may reveal regulatory loops involving both TFs and microRNAs. Th-cells, macrophages, or interleukins), indicating that it is possible to engineer cells displaying an adapted phenotype where: (a) towards mineralization is reinforced, (b) untoward mineral deposition is halted and finally (c) mutual musculoskeletal interactions are ‘reinforced’. The present work encompasses some data showing manipulations of HDACs, transcription factors (TFs), as well as microRNAs and the impact of vitamin K2 (MK-7) on mineralizing cells (osteoblasts) and striated muscle cells exposed to either normal growth conditions or mediators of inflammation (i.e. histone modifications, phenotype modifications through transcriptional control, via microRNA species) constitute forces, slowly tilting the cell phenotype towards a more or less stable profile.ĭespite this tendency, phenotypic characteristics could be subjected to alterations, that is, either weakened or reinforced, or even altered, resulting from underlying or developing diseases and/or gene therapy. This work shows how the interactive axis consisting of ‘Epigenator-Initiator-Maintainer’ components determines the ultimate phenotypes of the cellular functions or the chain of reactions within different body organs and tissues. Recently, an abstract entitled ‘Epigenetic factors involved in musculo-skeletal interaction - How skeletal muscle cells and osteoblasts derived from stem cells communicate with special reference to histone deacetylases (HDACS), transcription factors (TFs), microRNAs, and vitamin K2’ was presented at an OMICS conference in Chicago, USA.
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